Antimicrobial Resistance

What is AMR?

According to the World Health Organization (WHO), antimicrobial resistance (AMR) refers to a resistance to drugs that help treat infections caused by microbes such as parasites, viruses, and fungi.

AMR occurs naturally but is facilitated by the inappropriate use of medicine, as well as low-quality medicine, incorrect prescriptions, and poor infection prevention and control.

In fact, the rapid emergence and spread of AMR infections are exacerbated by the inappropriate use of antimicrobials in human and veterinary medicine and in the agriculture industry.

Why AMR is an issue

AMR has the potential to negatively impact the Canadian economy and healthcare sector in a significant way.

Economy :

  • As highlighted by a Council of Canadian Academies report, the Canadian economy has already began to shrink as a result of AMR, with increased deaths and a shrunken workforce due to illness.

  • The Council of Canadian Academies expert panel on the potential societal impacts of AMR in Canada predicts that AMR’s impact on labour productivity reduced Canada’s GDP by $2 billion in 2018.

  • The same panel predicts that by 2050, if resistance to first-line antimicrobials remains constant or increases, that AMR would reduce Canada’s GDP by $13 to $21 billion per year.

Healthcare :

  • A dramatic increase in AMR has the potential to imperial the Canadian healthcare system ability to treat life-threatening infections and carry out medical treatments where antibiotics play an important role.

  • If resistance rates continue to rise, they will lead to significant financial implications for Canada’s healthcare system.

  • By 2050, Canada’s healthcare costs as a result of increasing AMR would grow to about $6 to $8 billion per year.

As existing antibiotics lose their effectiveness, not enough new drugs are being created to replace them, due to various scientific and commercial barriers.
Considering these daunting figures, it is clear that AMR is a pressing issue that the government needs to continue committing towards efforts to address it.

When Antibiotics Fail

The growing cost of antimicrobial resistance in Canada

When Antibiotics Fail is an independent, evidence-based assessment of the potential socio-economic impact of AMR in Canada. Using existing data and a quantitative economic model, a panel of experts found that in Canada:

26%

In 2018, approximately 26% of infections were resistant to the drugs generally used to treat them.

40%

By 2050, the rate of resistance is likely to grow to 40%

AMR affects health

2018
26%

Resistance

0

lives lost per year in Canada as a direct result of AMR.

2050
40%

Resistance

0

lives lost each year as a direct result of AMR.

Most common infections:

  • Skin and soft tissue infections

  • Urinary tract infections

  • Intra-abdominal infections

  • Pneumonia

Most resistant infections:

  • Musculoskeletal infections

  • Skin and soft tissue infections
  • Urinary tract infections
  • Pneumonia/Intra-abdominal infections

AMR affects the health system

2018
26%

Resistance

AMR costs the Canadian healthcare system approximately

$0

billion
a year.

2050
40%

Resistance

AMR costs the Canadian healthcare system approximately

$0

billion
a year.

AMR could increase the risk and reduce the availability of routine medical procedures including:

  • Kidney dialysis

  • Joint replacement

  • Chemotherapy

  • Caesarian section

AMR affects the economy

2050
26%

Resistance

AMR reduces the Canadian GDP by

$0

billion
annually.

2050
40%

Resistance

AMR reduces the Canadian GDP by

$0

billion
annually.

The top five industries affected by AMR are:

  • Recreation and culture

  • Public service

  • Transportation

  • Animal Product Manufacturing

  • Manufacturing/Construction/Retail

If AMR increases gradually from 26% to 40%, by 2050, the cumulative cost to Canada is estimated at:

0
lives

$0
billion in hospital costs

$0
billion in GDP

AMR affects how we live, work, and connect

The social impacts of AMR may outweigh the economic costs, and they will be unequally distributed among Canadians.

The way forward

When Antibiotics Fail. The Expert Panel on the Socio-Economic Impacts of Antimicrobial Resistance in Canada (2019).

cca-reports.ca @cca_reports

What the government has done to address AMR

Canada has already recognized the threat of AMR and the urgent need for action with the Public Health Agency of Canada’s September 2017 release of a Pan-Canadian Framework for Action for Tackling Antimicrobial Resistance and Antimicrobial Use

The framework was the result of a coordinated effort between federal, provincial, and territorial governments, as well as academics, NGOs, and industry experts representing human and animal health and agriculture sectors at all levels

But there is still more work to be done! More action is necessary. Without new ways of diagnosing, preventing, and treating infections, Canada cannot overcome the challenges of AMR.

What the government can do

The Canadian Declaration on Antimicrobial Resistance, of which several CAIC members are signatories, outlines different ways that the government can help and take action against AMR.

The Declaration encourages the government to strengthen Canada’s end-to-end research capacity for antimicrobial innovation, beginning with surveillance and through to advanced testing, demonstration projects and post-market studies

The Declaration calls on government to work with stakeholders, such as CAIC, to establish new business models that will help improve access to new antibiotics, diagnostics and vaccines globally.

For more information

Industry Call to Action

Council of Canadian Academies

World Health Organization (WHO)